Molecular Plant Glycobiology
- Functional characterization of complex N-glycans in plants
- Investigation of glycan-dependent ER quality control systems in plants
- Investigation of mechanisms for subcellular localization of glycosylation enzymes
Plant N-glycan processing enzymes are arranged along the early secretory pathway, forming an assembly line in order to facilitate the step-by-step modification of oligosaccharides on glycoproteins. Thus, these enzymes provide excellent tools to study signals and mechanisms promoting their localization and retention in the ER and Golgi apparatus. Our main objective is the analysis of putative targeting motifs present in glycosidases and glycosyltransferases and the identification of interacting proteins to obtain new insights into this fundamental cellular process.
- O-glycan engineering in N. benthamiana
- Dicker M, Strasser R. Using glyco-engineering to produce therapeutic proteins. Expert Opin Biol Ther. 2015;15(10):1501-1516. doi: 10.1517/14712598.2015.1069271. Epub 2015 Jul 14. PDF
- Strasser R. (2018). Protein Quality Control in the Endoplasmic Reticulum of Plants. Annu Rev Plant Biol 69: 147-172. doi: 10.1146/annurev-arplant-042817-040331