News & Events


New publication from Adam Lab:

Chemical synthesis of culmorin metabolites and their biologic role in culmorin and acetyl-culmorin treated wheat cells

The Fusarium metabolite culmorin (1) is receiving increased attention as an “emerging mycotoxin”. It cooccurs with trichothecene mycotoxins and potentially influences their toxicity. Its ecological role and fate in plants is unknown. We synthesized sulfated and glucosylated culmorin conjugates as potential metabolites, which are expected to be formed in planta, and used them as reference compounds. An efficient procedure for the synthesis of culmorin sulfates was developed. Diastereo- and regioselective glucosylation of culmorin (1) was achieved by exploiting or preventing unexpected acyl transfer when using different glucosyl donors (read more)

New publication from Hauser Lab:

Root hair abundance impacts cadmium accumulation in Arabidopsis thaliana shoots

Background and Aims
Root hairs increase the contact area of roots with soil and thereby enhance the capacity for solute uptake. The strict hair/non-hair pattern of Arabidopsis thaliana can change with nutrient deficiency or exposure to toxic elements, which modify root hair density. The effects of root hair density on cadmium (Cd) accumulation in shoots of arabidopsis genotypes with altered root hair development and patterning were studied. (read more)

Latest pre-print from Elena Feraru (Kleine-Vehn Lab):

PILS6 is a temperature-sensitive regulator of nuclear auxin input and organ growth in Arabidopsis thaliana

Abstract
Global warming is threatening plant productivity, because plant growth is highly sensitive to elevated temperatures. High temperature (HT) triggers the auxin biosynthesis-dependent growth in aerial tissues. On the other hand, the contribution of auxin to HT-induced root growth is currently under debate. Here we show that the putative intracellular auxin carrier PIN-LIKES 6 (PILS6) is a negative regulator of organ growth and that its abundance is highly sensitive to HT.  (read more)

New publication from Adam Lab:

Less-toxic rearrangement products of NX-tHighlights

Highlights:

  • Characterization of three new rearrangement products of NX-toxins.
  • NX3-M1 shows diminished inhibitory effects on protein synthesis compared to NX-3.
  • NX3-M1 causes no significant cytotoxic effects in the two tested colon cell lines.
  • Extended storage of infected grain products results in reduced NX-3 content.
    (read more)

New publication with contribution from Strauss Lab:

Diversification of Transcriptional Regulation Determines Subfunctionalization of Paralogous Branched Chain Aminotransferases in the Yeast Saccharomyces cerevisiae

Abstract
Saccharomyces cerevisiae harbors BAT1 and BAT2 paralogous genes that encode branched chain aminotransferases and have opposed expression profiles and physiological roles . Accordingly, in primary nitrogen sources such as glutamine, BAT1 expression is induced, supporting Bat1-dependent valine–isoleucine–leucine (VIL) biosynthesis, while BAT2 expression is repressed. Conversely, in the presence of VIL as the sole nitrogen source, BAT1 expression is hindered while that of BAT2 is activated, resulting in Bat2-dependent VIL catabolism. (read more)